Skeletal Dysmorphology in Fetus Following Colloidal Silver Ingestion in Pregnant Swiss Albino Mice

The present industrial sector related to textile industry, medicine product industry, house hold industry have enormously spread the use of Silver nanoparticle. Varieties of teratogenic effects are executed due to silver nanoparticle among which one of the important is skeletal dysmorphology. The discovery of the new facts can be compared with the quotes from some studies [1] reveals that there is some chemical agents and drugs can induce teratogenic effects on the contrary silver nanoparticle induces skeletal dysmorphology in higher dose oral gavages schedules. On the due course of development it evokes major congenital abnormalities of various systems of offspring’s which is seen in developed countries like USA and Canada about 3 to 5% and in developing countries like India, Mauritania etc about 20 to 25% [2]. The devastating effects of drug, manually made colloidal solution, viruses and other facts related to our ecology is responsible for 1% of congenital defects of known and unknown etiology [3]. Old studies on in-vitro risk assessment reported silver nanoparticle translocation which causes decreased cell viability, cell membrane damage and other histological hazardous effects. Several other studies also indicated silver nanoparticle to be most toxic among all metal nanoparticles [4-6]. A toxicity of minimum level is denoted when HL-60 cell grown on metal silver plate. Some researchers did accumulation of nano silver on cells experiment [7-11] and denoted that maximum accumulation can be cytotoxic in rat liver cell and Mammalian germ line stem cells [12].